Neutralizing antibodies for the treatment of COVID-19
Neutralizing antibodies for the treatment of COVID-19 | Nature Biomedical Engineering Skip to
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High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme
There are currently few approved effective treatments for SARS-CoV-2, the virus responsible
for the COVID-19 pandemic. Nanobodies are 12–15 kDa single-domain antibody fragments …
for the COVID-19 pandemic. Nanobodies are 12–15 kDa single-domain antibody fragments …
[HTML][HTML] High potency of a bivalent human VH domain in SARS-CoV-2 animal models
Novel COVID-19 therapeutics are urgently needed. We generated a phage-displayed
human antibody VH domain library from which we identified a high-affinity VH binder ab8 …
human antibody VH domain library from which we identified a high-affinity VH binder ab8 …
Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy
C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …
Role of antibody-dependent enhancement (ADE) in the virulence of SARS-CoV-2 and its mitigation strategies for the development of vaccines and immunotherapies …
K Karthik, TMA Senthilkumar… - Human vaccines & …, 2020 - Taylor & Francis
ABSTRACT Coronavirus disease-2019 (COVID-19) pandemic has become a global threat
and death tolls are increasing worldwide. The SARS-CoV-2 though shares similarities with …
and death tolls are increasing worldwide. The SARS-CoV-2 though shares similarities with …
Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
Abstract The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …
An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants
X Chi, X Zhang, S Pan, Y Yu, Y Shi, T Lin… - Signal transduction and …, 2022 - nature.com
The wide transmission and host adaptation of SARS-CoV-2 have led to the rapid
accumulation of mutations, posing significant challenges to the effectiveness of vaccines …
accumulation of mutations, posing significant challenges to the effectiveness of vaccines …
Development of multivalent nanobodies blocking SARS-CoV-2 infection by targeting RBD of spike protein
Q Lu, Z Zhang, H Li, K Zhong, Q Zhao, Z Wang… - Journal of …, 2021 - Springer
Background The outbreak and pandemic of coronavirus SARS-CoV-2 caused significant
threaten to global public health and economic consequences. It is extremely urgent that …
threaten to global public health and economic consequences. It is extremely urgent that …
Spherical neutralizing aptamer inhibits SARS-CoV-2 infection and suppresses mutational escape
M Sun, S Liu, T Song, F Chen, J Zhang… - Journal of the …, 2021 - ACS Publications
New neutralizing agents against SARS-CoV-2 and associated mutant strains are urgently
needed for the treatment and prophylaxis of COVID-19. Herein, we develop a spherical …
needed for the treatment and prophylaxis of COVID-19. Herein, we develop a spherical …
Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy
KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …