A vexing observation in genome-wide association studies (GWASs) is that parallel analyses
in different species may not identify orthologous genes. Here, we demonstrate that cross …

Motivation Enhancers are vital cis-regulatory elements that regulate gene expression.
Enhancer RNAs (eRNAs), a type of long noncoding RNAs, are transcribed from enhancer …

Enhancer-gene communication is dependent on topologically associating domains (TADs)
and boundaries enforced by the CCCTC-binding factor (CTCF) insulator, but the underlying …

Although promoters and their enhancers are frequently contained within a topologically
associating domain (TAD), some developmentally important genes have their promoter and …

Background and aims: N6-methyladenosine (m6A) is the most common post-transcriptional
modification on eukaryotic mRNA, affecting mRNA's fate. The role of m6A regulation in …

Background Enhancers are essential in defining cell fates through the control of cell-type-
specific gene expression. Enhancer activation is a multi-step process involving chromatin …

How to effectively convert genomic summary data into downstream knowledge discovery
represents a major challenge in human genomics research. To address this challenge, we …

To better understand DNA methylation in Alzheimer's disease (AD) from both mechanistic
and biomarker perspectives, we performed an epigenome-wide meta-analysis of blood DNA …

Genome‐wide association studies have revealed a plethora of genetic variants that
correlate with polygenic conditions. However, causal molecular mechanisms have proven …

Background A genome-wide association study (GWAS) correlates variation in the genotype
with variation in the phenotype across a cohort, but the causal gene mediating that impact is …