Sleep is a vital segment of life, however, the mechanisms of diet promoting sleep are
unclear and are the focus of research. Insomnia is a general sleep disorder and functional …

Objective Genetic variations can affect individual response to methadone maintenance
treatment (MMT) for heroin addiction. The A118G variant (rs1799971) in the mu opioid …

Methadone is the major opioid substitution therapy for opioid dependence. Dosage is highly
variable and is often controlled by the patient and prescriber according to local and national …

The efficacy of methadone maintenance treatment (MMT) in opioid use disorder is well
established but responses vary. The influence of methadone pharmacodynamics and …

Opioids are the cornerstone of analgesic therapy and are used as a substitution therapy for
opiate addiction. Interindividual variability in response to opioids is a significant challenge in …

Background: The experience of chronic non-cancer pain (CNCP) is one of the most common
reasons individuals seek medical attention. Patients with CNCP frequently experience …

Background There is no countable biomarker for opioid dependence treatment responses
thus far. In this study, we recruited Taiwanese methadone maintenance treatment patients to …

Objective: To explore the association between methadone dosage, plasma drug
concentration, SNPs of μ-opioid receptor gene (OPRM1), ATP-binding cassette subfamily B …

Next-generation sequencing (NGS) provides unrestricted access to the genome, but it
produces 'big data'exceeding in amount and complexity the classical analytical approaches …

Previous studies have shown significant associations between OPRK1 and susceptibility to
opioid dependence and the relationships between libido dysfunction and insomnia among …