OPRM1 gene encoding mu-opioid receptor (MOR) is the primary candidate gene for
buprenorphine (BUP) pharmacogenetics. OPRM1 undergoes alternative splicing leading to …

An increased awareness on neonatal pain-associated complications has led to the
development of pain scales adequate to assess the level of pain experienced by newborns …

Background: Heroin use disorder (HUD) is a complex brain disease that includes multiple
phenotypes. Heroin acts primarily as a mu-opioid receptor (OPRM1) agonist. The κ opioid …

Aim: Methadone is a long-acting opioid receptor agonist. It is prescribed to patients with
opioid-related use disorders. The OPRM1 gene encodes for methadone's main receptor. It …

Drug addiction is a serious relapsing disease that has high costs to society and to the
individual addicts. Treatment of these addictions is still in its nascency, with only a few …

Introduction Methadone is a full agonist of the opioid receptor mu 1 which is encoded by the
OPRM1 gene. Sleep disorders were frequently reported by opioid-dependent patients …

Introduction Sleep disturbance is a major health concern for heroin users receiving
methadone maintenance treatment (MMT). The present study was aimed to investigate the …

Aim. Poor sleep quality due to pain has been reported among opioid-dependent male
patients on methadone maintenance therapy (MMT) but objective pain data are lacking. This …

The associations of OPRM1 gene variants with opioid dependence have been
demonstrated. This study investigated the association of rs495491, rs1799971 (A118G) …

Background Investigations proposed that genetic polymorphisms within proteins in
methadone pharmacokinetic and pharmacodynamics are critical factors in determination of …