A Panorama of Extracellular Vesicle Applications: From Biomarker Detection to Therapeutics

S Das, CJ Lyon, T Hu - ACS nano, 2024 - ACS Publications
Extracellular vesicles (EVs) secreted by all cell types are involved in the cell-to-cell transfer
of regulatory factors that influence cell and tissue phenotypes in normal and diseased …

[HTML][HTML] Improving cancer immunotherapy by preventing cancer stem cell and immune cell linking in the tumor microenvironment

D Li, L Wang, B Jiang, Y Jing, X Li - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Cancer stem cells are the key link between malignant tumor progression and drug
resistance. This cell population has special properties that are different from those of …

[HTML][HTML] Exosomes derived from CD271+ CD56+ bone marrow mesenchymal stem cell subpopoulation identified by single-cell RNA sequencing promote axon …

Y Sun, Q Liu, Y Qin, Y Xu, J Zhao, Y Xie, C Li, T Qin… - Theranostics, 2024 - ncbi.nlm.nih.gov
Rationale: Spinal cord injury (SCI) results in neural tissue damage. However, the limited
regenerative capacity of adult mammals' axons upon SCI leads to persistent neurological …

[HTML][HTML] Intravenous Administration of Mesenchymal Stem Cell-Derived Exosome Alleviates Spinal Cord Injury by Regulating Neutrophil Extracellular Trap Formation …

Y Morishima, M Kawabori, K Yamazaki… - International Journal of …, 2024 - mdpi.com
Spinal cord injury (SCI) leads to devastating sequelae, demanding effective treatments.
Recent advancements have unveiled the role of neutrophil extracellular traps (NETs) …

Extracellular Vesicle Spherical Nucleic Acids

H Chen, Q Ding, L Li, P Wei, Z Niu, T Kong, P Fu… - JACS Au, 2024 - ACS Publications
Extracellular vesicles (EVs) are naturally occurring vesicles secreted by cells that can
transport cargo between cells, making them promising bioactive nanomaterials. However …

[HTML][HTML] Cellular and Noncellular Approaches for Repairing the Damaged Blood–CNS–Barrier in Amyotrophic Lateral Sclerosis

L Manora, CV Borlongan, S Garbuzova-Davis - Cells, 2024 - mdpi.com
Numerous reports have demonstrated the breakdown of the blood–CNS barrier (B-CNS-B)
in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Re-establishing …

[HTML][HTML] Nanosystems-enabled regenerative strategies for spinal cord Injury: Recent advances and future prospects

Z Jia, W Li - Materials & Design, 2023 - Elsevier
Spinal cord injury (SCI) is a debilitating condition with limited treatment options,
necessitating the exploration of innovative regenerative approaches. Nanosystems have …

Dual-functional gallium/chitosan/silk/umbilical cord mesenchymal stem cell exosome sponge scaffold for diabetic wound by angiogenesis and antibacteria

X Shi, Y Li, S Kang, X Zhao, L Liu, F Yuan, L He… - International Journal of …, 2024 - Elsevier
The treatment of diabetic wounds possessed significant challenges in clinical practice,
which was accompanied with continuous infection, inflammation, and limited angiogenesis …

Ginsenoside Rg1 Regulates Immune Microenvironment and Neurological Recovery After Spinal Cord Injury Through MYCBP2 Delivery via Neuronal Cell‐Derived …

Y Rong, J Wang, T Hu, Z Shi, C Lang, W Liu… - Advanced …, 2024 - Wiley Online Library
Spinal cord injury (SCI) is a severe neurological condition that frequently leads to significant
sensory, motor, and autonomic dysfunction. This study sought to delineate the potential …

[HTML][HTML] Functional biomaterials for modulating the dysfunctional pathological microenvironment of spinal cord injury

D Ma, C Fu, F Li, R Ruan, Y Lin, X Li, M Li, J Zhang - Bioactive Materials, 2024 - Elsevier
Spinal cord injury (SCI) often results in irreversible loss of sensory and motor functions, and
most SCIs are incurable with current medical practice. One of the hardest challenges in …