Cancer stem cells (CSCs) are a tumour subpopulation whose capacity for self-renewal,
differentiation and proliferation generates unfavourable patient outcomes, including …

Abstract Purpose: Androgen receptor (AR)-targeting prostate cancer drugs, which are
predominantly competitive ligand-binding domain (LBD)-binding antagonists, are …

Therapy resistance hinders the efficacy of anti-androgen therapies and taxane-based
chemotherapy for advanced prostate cancer (PCa). Glucocorticoid receptor (GR) signaling …

Cancer progression is characterized and driven by gradual loss of a differentiated
phenotype and gain of stem cell-like features. In prostate cancer (PCa), androgen receptor …

Prostate cancer (CaP) driven by androgen receptor (AR) is treated with androgen
deprivation; however, therapy failure results in lethal castration-resistant prostate cancer …

Prostate cancer (PCa) is a malignant epithelial tumor of the prostate gland with a high male
cancer incidence. Numerous studies indicate that abnormal function of ubiquitin …

Several types of K+ channels play crucial roles in tumorigenicity, stemness, invasiveness,
and drug resistance in cancer. Spheroid formation of human prostate cancer (PC) LNCaP …

Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative and neuromuscular
genetic disease caused by the expansion of a polyglutamine-encoding CAG tract in the …

Per-and polyfluorinated alkyl substances (PFAS) are a large family of widely used synthetic
chemicals that are environmentally and biologically persistent and present in most …

Simple Summary In this study, we demonstrate the potential role of VNPP433-3β as
molecular glue that induces physical proximity between the Androgen Receptor and MDM2 …