Our understanding of the classical MHC class I molecules (MHC class Ia molecules) has
long focused on their extreme polymorphism. These molecules present peptides to T cells …

Natural killer (NK) cells have been implicated in innate immune responses against viruses
such as herpesviruses, which cause persistent infections in the host. In response to the …

During mouse cytomegalovirus (CMV) infection, a population of Ly49H+ natural killer (NK)
cells expands and is responsible for disease clearance through the induction of a “memory …

Natural killer (NK) cells are known to mount a rapid response to several virus infections. In
experimental models of acute viral infection, this response has been characterized by …

CD94/NKG2C+ natural killer (NK) cells are increased in healthy individuals infected with
human cytomegalovirus (HCMV), suggesting that HCMV infection may shape the NK cell …

CD8+ T cells not only are critical mediators of adaptive immunity but also may exhibit innate-
like properties such as surface expression of NKG2C, an activating receptor typically …

Human cytomegalovirus (HCMV) has become a paradigm for viral immune evasion due to
its unique multitude of immune-modulatory strategies. HCMV modulates the innate as well …

As discussed in this review, human cytomegalovirus (HCMV) infection in healthy individuals
is associated with a variable and persistent increase of NK cells expressing the …

In rodents, liver natural killer (NK) cells have been shown to mediate higher cytotoxic activity
against tumor cells than do peripheral blood (PB) NK cells. However, such differences …

Immune responses must be tightly regulated to avoid hyporesponsiveness on one hand or
excessive inflammation and the development of autoimmunity (hyperresponsiveness) on the …