[HTML][HTML] Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives

H Liu, Q Zhang, S Wang, W Weng, Y Jing, J Su - Bioactive Materials, 2022 - Elsevier
Nanosized extracellular vesicles derived from bacteria contain diverse cargo and transfer
intercellular bioactive molecules to cells. Due to their favorable intercellular interactions, cell …

[HTML][HTML] Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy

H Liu, H Zhang, Y Han, Y Hu, Z Geng, J Su - Theranostics, 2022 - ncbi.nlm.nih.gov
Bone and soft tissue tumors are complex mesenchymal neoplasms that seriously endanger
human health. Over the past decade, the relationship between microorganisms and human …

Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling

J Xie, L Cools, G Van Imschoot… - Journal of …, 2023 - Wiley Online Library
The gut microbiota represents a diverse and dynamic population of microorganisms that can
influence the health of the host. Increasing evidence supports the role of the gut microbiota …

Bacterial extracellular vesicles: an emerging avenue to tackle diseases

J Xie, F Haesebrouck, L Van Hoecke… - Trends in …, 2023 - cell.com
A growing body of research, especially in recent years, has shown that bacterial
extracellular vesicles (bEVs) are one of the key underlying mechanisms behind the …

A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria

L Yao, GD D'Agostino, J Park, S Hang… - Nature …, 2022 - nature.com
Members of the human gut microbiome enzymatically process many bioactive molecules in
the gastrointestinal tract. Most gut bacterial modifications characterized so far are hydrolytic …

[HTML][HTML] Engineered bacterial extracellular vesicles for osteoporosis therapy

H Liu, M Li, T Zhang, X Liu, H Zhang, Z Geng… - Chemical Engineering …, 2022 - Elsevier
Osteoporosis (OP) is a systemic bone disease characterized by reduction of bone mass and
destruction of structure, which can easily lead to fragility fractures. Over the past decade, an …

Mass‐produced gram‐negative bacterial outer membrane vesicles activate cancer antigen‐specific stem‐like CD8+ T cells which enables an effective combination …

S Won, C Lee, S Bae, J Lee, D Choi… - Journal of …, 2023 - Wiley Online Library
Despite the capability of extracellular vesicles (EVs) derived from Gram‐negative and Gram‐
positive bacteria to induce potent anti‐tumour responses, large‐scale production of bacterial …

Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in …

T Gong, Q Chen, H Mao, Y Zhang, H Ren… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Porphyromonas gingivalis (Pg), the keystone pathogen in chronic periodontitis,
is reported to initiate Alzheimer's disease pathologies in preclinical studies. However, the …

Current knowledge and future perspectives of exosomes as nanocarriers in diagnosis and treatment of diseases

Z Zou, H Li, G Xu, Y Hu, W Zhang… - International Journal of …, 2023 - Taylor & Francis
Exosomes, as natural nanocarriers, characterized with low immunogenicity, non-cytotoxicity
and targeted delivery capability, which have advantages over synthetic nanocarriers …

Single‐particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier

Z Ou, B Situ, X Huang, Y Xue, X He, Q Li… - Journal of …, 2023 - Wiley Online Library
Bacterial extracellular vesicles (BEVs) are nano‐size particles secreted by bacteria that
carry various bioactive components. These vesicles are thought to provide a new window …