Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens
Multivalent presentation of viral glycoproteins can substantially increase the elicitation of
antigen-specific antibodies. To enable a new generation of anti-viral vaccines, we designed …
antigen-specific antibodies. To enable a new generation of anti-viral vaccines, we designed …
Stabilized coronavirus spike stem elicits a broadly protective antibody
Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1
subunit, which are poorly conserved and susceptible to escape mutations, thus threatening …
subunit, which are poorly conserved and susceptible to escape mutations, thus threatening …
Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies
Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine
development. VRC01-class bnAbs are important vaccine leads because their precursor B …
development. VRC01-class bnAbs are important vaccine leads because their precursor B …
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
As the sole viral antigen on the HIV-1–virion surface, trimeric Env is a focus of vaccine
efforts. Here we present the structure of the ligand-free HIV-1–Env trimer, fix its conformation …
efforts. Here we present the structure of the ligand-free HIV-1–Env trimer, fix its conformation …
Identification and specificity of broadly neutralizing antibodies against HIV
LE McCoy, DR Burton - Immunological reviews, 2017 - Wiley Online Library
Beginning in 2009, studies of the humoral responses of HIV‐positive individuals have led to
the identification of scores, if not hundreds, of antibodies that are both broadly reactive and …
the identification of scores, if not hundreds, of antibodies that are both broadly reactive and …
Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination
Sustained exposure of lymphoid tissues to vaccine antigens promotes humoral immunity,
but traditional bolus immunizations lead to rapid antigen clearance. We describe a …
but traditional bolus immunizations lead to rapid antigen clearance. We describe a …
Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort
E Landais, X Huang, C Havenar-Daughton… - PLoS …, 2016 - journals.plos.org
Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a
protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has …
protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has …
Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein
AJ Behrens, S Vasiljevic, LK Pritchard, DJ Harvey… - Cell reports, 2016 - cell.com
The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that
shield it from immune surveillance. The high density of glycans on the trimer surface …
shield it from immune surveillance. The high density of glycans on the trimer surface …
[HTML][HTML] Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors
Broadly neutralizing antibodies (bnAbs) to the HIV envelope (Env) V2-apex region are
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an …
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers
All previously characterized broadly neutralizing antibodies to the HIV-1 envelope
glycoprotein (Env) target one of four major sites of vulnerability. Here, we define and …
glycoprotein (Env) target one of four major sites of vulnerability. Here, we define and …