[PDF][PDF] T-cell receptor repertoire sequencing in the era of cancer immunotherapy

ML Frank, K Lu, C Erdogan, Y Han, J Hu, T Wang… - Clinical Cancer …, 2023 - AACR
T cells are integral components of the adaptive immune system, and their responses are
mediated by unique T-cell receptors (TCR) that recognize specific antigens from a variety of …

The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria

MJ Boyle, CR Engwerda, P Jagannathan - Nature Reviews …, 2024 - nature.com
Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory
responses across the immune landscape. These regulatory responses help to protect …

[HTML][HTML] Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model

J Ludwig, SW Scally, G Costa, S Hoffmann, R Murugan… - npj Vaccines, 2023 - nature.com
The development of an effective and durable vaccine remains a central goal in the fight
against malaria. Circumsporozoite protein (CSP) is the major surface protein of sporozoites …

Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies

OE Oludada, G Costa, C Burn Aschner… - EMBO Molecular …, 2023 - embopress.org
Human monoclonal antibodies (mAbs) against the central repeat and junction domain of
Plasmodium falciparum circumsporozoite protein (PfCSP) have been studied extensively to …

Progress in vaccine development for infectious diseases—a Keystone Symposia report

J Cable, BS Graham, RA Koup… - Annals of the New …, 2023 - Wiley Online Library
The COVID‐19 pandemic has taught us many things, among the most important of which is
that vaccines are one of the cornerstones of public health that help make modern longevity …

[HTML][HTML] CD8+ Trms against malaria liver-stage: prospects and challenges

C Zhu, S Jiao, W Xu - Frontiers in Immunology, 2024 - frontiersin.org
Attenuated sporozoites provide a valuable model for exploring protective immunity against
the malarial liver stage, guiding the design of highly efficient vaccines to prevent malaria …

Developing a physiologic model of placental malaria in mice

POA Ekregbesi - 2024 - jscholarship.library.jhu.edu
Pregnant women in malaria-endemic regions are at greater risk than to non-pregnant adults
for complications associated with malaria infection, in part because of malaria infection of …

Characterization of human antibodies against Plasmodium falciparum circumsporozoite protein (PfCSP) epitopes

OE Oludada - 2024 - archiv.ub.uni-heidelberg.de
Plasmodium falciparum malaria, a mosquito-borne, unicellular parasitic disease, remains a
major health concern, particularly in the sub-Saharan Africa. Despite many attempts to …