Epidemiological evidence indicates the presence of dysregulated homeostatic biological
pathways in depressed patients, such as increased inflammation and disrupted energy …

Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

A common belief among statistical geneticists is that genomewide association studies
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Genome-wide association studies on human behavioural traits are producing large amounts
of polygenic signals with significant predictive power and potentially useful biological clues …

DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …

Behavior genetics studies how genetic differences among people contribute to differences in
their psychology and behavior. Here, I describe how the conclusions and methods of …

Abstract Analysis of secondary data sources (such as cohort studies, survey data, and
administrative records) has the potential to provide answers to science and society's most …

An" elegant"," engrossing"(Carol Tavris, Wall Street Journal) examination of what we think
we know about the brain and why--despite technological advances--the workings of our …

Evidence that offspring traits can be shaped by parental life experiences in an epigenetically
inherited manner paves a way for understanding the etiology of depression. Here, we show …