[HTML][HTML] Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV disease and posttreatment control in children

NG Herbert, PJR Goulder - Current Opinion in HIV and AIDS, 2023 - journals.lww.com
Impact of early antiretroviral therapy, early life immunity... : Current Opinion in HIV and AIDS
Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV …

HIV post-treatment controllers have distinct immunological and virological features

B Etemad, X Sun, Y Li, M Melberg… - Proceedings of the …, 2023 - National Acad Sciences
HIV post-treatment controllers (PTCs) are rare individuals who maintain low levels of viremia
after stopping antiretroviral therapy (ART). Understanding the mechanisms of HIV post …

[HTML][HTML] Immunomodulatory activity of the tyrosine kinase inhibitor dasatinib to elicit NK cytotoxicity against cancer, HIV infection and aging

A Rodríguez-Agustín, V Casanova, J Grau-Expósito… - Pharmaceutics, 2023 - mdpi.com
Tyrosine kinase inhibitors (TKIs) have been extensively used as a treatment for chronic
myeloid leukemia (CML). Dasatinib is a broad-spectrum TKI with off-target effects that give it …

[HTML][HTML] Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health

NR Pollock, GF Harrison, PJ Norman - The Journal of Allergy and Clinical …, 2022 - Elsevier
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …

Sustained aviraemia despite anti-retroviral therapy non-adherence in male children following in utero hiv transmission

N Bengu, G Cromhout, E Adland, K Govender… - Nature Medicine, 2024 - nature.com
Following sporadic reports of post-treatment control of HIV in children who initiated
combination antiretroviral therapy (cART) early, we here prospectively studied 284 very …

[HTML][HTML] Immune correlates of HIV-1 reservoir cell decline in early-treated infants

CA Hartana, P Garcia-Broncano, Y Rassadkina, X Lian… - Cell Reports, 2022 - cell.com
Initiation of antiretroviral therapy (ART) in infected neonates within hours after birth limits
viral reservoir seeding but does not prevent long-term HIV-1 persistence. Here, we report …

[HTML][HTML] Natural killer cells in antibody independent and antibody dependent HIV control

NF Bernard, S Kant, Z Kiani, C Tremblay… - Frontiers in …, 2022 - frontiersin.org
Infection with the human immunodeficiency virus (HIV), when left untreated, typically leads to
disease progression towards acquired immunodeficiency syndrome. Some people living …

[HTML][HTML] Thirteen-year viral suppression and immunologic recovery of LPV/r-based regimens in pediatric HIV treatment: a multicenter cohort study in resource …

X Lao, H Zhang, L Yan, H Zhao, Q Zhao, H Lu… - Frontiers in …, 2023 - frontiersin.org
Background Antiretroviral Therapy (ART) in children remains challenging due to resource-
constrained settings. We conducted a 13-year, prospective, multicenter cohort study on the …

[HTML][HTML] Role of Early Life Cytotoxic T Lymphocyte and Natural Killer Cell Immunity in Paediatric HIV Cure/Remission in the Anti-Retroviral Therapy Era

VA Vieira, N Herbert, G Cromhout, E Adland… - Frontiers in …, 2022 - frontiersin.org
Only three well-characterised cases of functional cure have been described in paediatric
HIV infection over the past decade. This underlines the fact that early initiation of …

[HTML][HTML] Longitudinal analysis of innate immune system in infants with perinatal HIV infection until 18 months of age

V Dinh, LR de Armas, S Pallikkuth, R Pahwa, S Rinaldi… - bioRxiv, 2023 - ncbi.nlm.nih.gov
With the advent of antiretroviral therapy (ART), perinatal HIV infection is declining globally
but prevalence in Sub-Saharan Africa is still greater than other nations. The relationship of …