Effects of anticholinesterases and of sodium fluoride on neuromyal desensitization

T Akasu, AG Karczmar - Neuropharmacology, 1980 - Elsevier
Desensitization of amphibian neuromyal junction was obtained by either repetitive, brief (2
msec) iontophoretic pulses of acetylcholine (ACh) or by a prolonged (40 sec) iontophoretic …

Neuromyopharmacology as related to anticholinesterase action

AG Karczmar, Y Ohta - Fundamental and Applied Toxicology, 1981 - Elsevier
Skeletal neuromyal (NM) junction is one of the primary targets of either acute or chronic
action of anticholinesterases (antiChE's) generally and of organophosphorus (OP) ChE …

Brain neuronal RNA metabolism during acute soman toxication: Effects of antidotal pretreatments

JA Doebler, TMA Bocan, RA Moore, TM Shih… - Neurochemical …, 1983 - Springer
Abstract Effects of various antidotal treatments on neuronal RNA contents and on soman
induced RNA and acetylcholinesterase (AChE) depletion were monitored using quantitative …

Physiological cholinergic functions in the CNS

AG Karczmar - Progress in Brain Research, 1990 - Elsevier
Publisher Summary This chapter discusses the physiological cholinergic functions in the
central nervous system (CNS). The seventh meeting of the Informal International Cholinergic …

The anti-curare action of sodium fluoride at the neuromuscular junction of cat tenuissimus muscle

RS Jacobs, LC Blaber - Neuropharmacology, 1971 - Elsevier
The anti-curare action of sodium fluoride was investigated in cat tenuissimus muscle by
means of intracellular micro-electrode techniques. Eight millimoles of sodium fluoride …

Synaptic modulations

AG Karczmar, S Nishi, LC Blaber - Brain and Human behavior, 1972 - Springer
While the transmission across the neuromyal junction and the resulting muscle contraction
looked relatively simple to Descartes as he believed that, during the muscle activity, the …

The mode of action of fluoride ions on neuromuscular transmission in frogs

K Kaibara, K Kuba, K Koketsu, AG Karczmar - Neuropharmacology, 1978 - Elsevier
This investigation deals with the effects of fluoride ion (F−) on the frog sciatic nerve-sartorius
muscle preparation; intracellular recording and voltage clamp techniques were employed …

Facilitatory sites of action of theophylline in isolated cat tenuissimus muscle

RS Jacobs, PL Shinnick - Neuropharmacology, 1973 - Elsevier
Facilitatory effects of theophylline in neuromuscular transmission were studied using cat
tenuissimus muscle fibre. Trains of end-plate potentials (EPP'S), in the presence and …

Ephedrine and neuromuscular transmission in vivo

JP Gallagher, P Shinnick-Gallagher - Neuropharmacology, 1979 - Elsevier
Ephedrine produced either facilitation or depression of indirectly evoked muscle
contractions. Facilitation occurred at lower doses (< 1 mg, close-arterially) and when slower …

Postsynaptic facilitatory effects of theophylline on amphibian neuromyal transmission.

K Kaibara, AG Karczmar - Journal of Pharmacology and Experimental …, 1978 - ASPET
This study concerns the effects of theophylline on nerve-muscle transmission of the frog; it
was of particular interest to evaluate the facilitatory actions of theophylline at the …