Background: There is a growing interest in the use of cannabis (and its extracts), as well as
CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is …

Cannabis (also known as marijuana) is the most frequently used illicit psychoactive
substance in the world. Though it was long considered to be a “soft” drug, studies have …

Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

The last decades have seen a major gain in understanding the action of cannabinoids and
the endocannabinoid system in reward processing and the development of addictive …

Substance use disorder is characterized by repeated use of a substance, leading to
clinically significant distress, making it a serious public health concern. The …

Cocaine abuse continues to be a serious health problem worldwide. Despite intense
research there is currently no FDA-approved medication to treat cocaine use disorder. The …

Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …

Background: Dietary essential omega-6 (n-6) and omega-3 (n-3) 18 carbon (18C-)
polyunsaturated fatty acids (PUFA), linoleic acid (LA) and α-linolenic acid (ALA), can be …

Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These
receptors are also the primary molecular target responsible for the pharmacological effects …

ABSTRACT Background and Aims Cocaine use disorder (CUD) is a significant public health
concern for which no efficacious pharmacological interventions are available. Cannabidiol …