COVID-19 therapeutics: Challenges and directions for the future

PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …

American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19

A Cuker, EK Tseng, R Nieuwlaat… - Blood …, 2021 - ashpublications.org
Background: Coronavirus disease 2019 (COVID-19)–related critical illness and acute illness
are associated with a risk of venous thromboembolism (VTE). Objective: These evidence …

Effect of intermediate-dose vs standard-dose prophylactic anticoagulation on thrombotic events, extracorporeal membrane oxygenation treatment, or mortality among …

S Mazloomzadeh, S Khaleghparast, B Ghadrdoost… - Jama, 2021 - jamanetwork.com
Importance Thrombotic events are commonly reported in critically ill patients with COVID-19.
Limited data exist to guide the intensity of antithrombotic prophylaxis. Objective To evaluate …

[HTML][HTML] Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: a systematic review and meta-analysis

MB Malas, IN Naazie, N Elsayed, A Mathlouthi… - …, 2020 - thelancet.com
Background Studies have suggested that there is increased risk of thromboembolism (TE)
associated with coronavirus disease 2019 (COVID-19). However, overall arterial and …

[HTML][HTML] Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

L Perico, A Benigni, F Casiraghi, LFP Ng… - Nature Reviews …, 2021 - nature.com
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …

The impact of COVID-19 disease on platelets and coagulation

GD Wool, JL Miller - Pathobiology, 2021 - karger.com
Abstract Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some
patients develop a severe proinflammatory state which can be associated with a unique …

Pulmonary embolism and deep vein thrombosis in COVID-19: a systematic review and meta-analysis

YJ Suh, H Hong, M Ohana, F Bompard, MP Revel… - Radiology, 2021 - pubs.rsna.org
Background The association of pulmonary embolism (PE) with deep vein thrombosis (DVT)
in patients with coronavirus disease 2019 (COVID-19) remains unclear, and the diagnostic …

Incidence of VTE and bleeding among hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis

D Jiménez, A García-Sanchez, P Rali, A Muriel… - Chest, 2021 - Elsevier
Background Individual studies have reported widely variable rates for VTE and bleeding
among hospitalized patients with coronavirus disease 2019 (COVID-19). Research Question …

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

G Goshua, AB Pine, ML Meizlish, CH Chang… - The Lancet …, 2020 - thelancet.com
Background An important feature of severe acute respiratory syndrome coronavirus 2
pathogenesis is COVID-19-associated coagulopathy, characterised by increased thrombotic …

COVID-19: from an acute to chronic disease? Potential long-term health consequences

V Higgins, D Sohaei, EP Diamandis… - Critical reviews in …, 2021 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). Despite pulmonary impairments being the most …