Background Impetigo is a common, superficial bacterial skin infection, which is most
frequently encountered in children. There is no generally agreed standard therapy, and …

Microbial infections have significantly increased over the last decades, and the mortality
rates remain unacceptably high. The emergence of new resistance patterns and the spread …

The emergence of bacterial multidrug resistance to antibiotics threatens to cause regression
to the preantibiotic era. Here we present the crystal structure of the large ribosomal subunit …

New insights into functional flexibility at the peptidyl transferase center (PTC) and its vicinity
were obtained by analysis of pleuromutilins binding modes to the ribosome. The crystal …

Impetigo is a common cutaneous infection that is especially prevalent in children. The
prevalence of colonization and infection with resistant strains is continually increasing …

Background: Retapamulin is a novel pleuromutilin antibacterial developed for topical use.
Objective: To compare the efficacy and safety of retapamulin ointment, 1%(twice daily for 5 …

Background Impetigo is a common skin infection, primarily caused by Staphylococcus
aureus and mainly occurring in children. It is usually treated topically with antibiotics to …

Aim: We compared the efficacy and safety of ozenoxacin (a new nonfluorinated quinolone)
1% cream with placebo in the treatment of impetigo. Patients & methods: In a randomized …

Summary Abstract Topical retapamulin (Altabax™, Altargo®) is the first pleuromutilin
antibacterial approved for the treatment of uncomplicated superficial skin infections caused …

Filamentous fungi produce a plethora of bioactive natural products. These metabolites
display a broad range of useful activities for pharmaceutical purposes, exemplified best by …