The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

Recent scientific discoveries that resulted from the application of next-generation DNA
sequencing technologies highlight the striking impact of these massively parallel platforms …

Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides
thorough coverage of the methods and practical elements of Mendelian randomization …

Presents the Terminology and Methods of Mendelian Randomization for Epidemiological
StudiesMendelian randomization uses genetic instrumental variables to make inferences …

Background A critical step in uncovering rules of RNA processing is to study the in vivo
regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation …

As vertebrate genome sequences near completion and research refocuses to their analysis,
the issue of effective genome annotation display becomes critical. A mature web tool for …

Chromosome-scale genome sequence assemblies underpin pan-genomic studies. Recent
genome assembly efforts in the large-genome Triticeae crops wheat and barley have relied …

Chemical modifications to DNA and histone proteins form a complex regulatory network that
modulates chromatin structure and genome function. The epigenome refers to the complete …

The vast majority of mental illnesses can be conceptualized as developmental disorders of
neural interactions within the connectome, or developmental miswiring. The recent …