Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific
pore in the inner mitochondrial membrane, known as the mitochondrial permeability …

Environmental stresses converge on the mitochondria that can trigger or inhibit cell death.
Excitable, postmitotic cells, in response to sublethal noxious stress, engage mechanisms …

Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

TNFα is crucially involved in the pathogenesis and progression of atherosclerosis,
myocardial ischemia/reperfusion injury and heart failure. The formation and release of TNFα …

Administration of nitric oxide (NO), NO donors or drugs that enhance NO realease (statins,
calcium antagonists, ACE-inhibitors, dexamethasone) prior to ischemia protects the …

Like Dr. Jeckyll and Mr. Hyde, mitochondria possess two distinct persona. Under normal
physiological conditions they synthesise ATP to meet the energy needs of the beating heart …

Background—Myocardial and renal injury commonly contribute to perioperative morbidity
and mortality after abdominal aortic aneurysm repair. Remote ischemic preconditioning …

Proteins of the interleukin-6 (IL-6) family bind to receptors in the plasma membrane.
Subsequent signal transduction involves activation of the janus kinase (JAK) and signal …

There appears to be a controversy in the study of myocardial ischaemia‐reperfusion injury
and preconditioning whether nitric oxide (NO) plays a protective or detrimental role. A …