Mdm2 promotes odontoblast-like differentiation by ubiquitinating Dlx3 and p53

H Zheng, G Yang, J Fu, Z Chen… - Journal of dental …, 2020 - journals.sagepub.com
Dentin is an important structural component of the tooth. Odontoblast differentiation is an
essential biological process that guarantees normal dentin formation, which is precisely …

JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling

Y Ren, D Chen, Z Zhai, J Chen, A Li, Y Liang… - Cell death …, 2021 - nature.com
The overexpression of HER2 is associated with a malignant proliferation of breast cancer. In
this study, we developed a non-cytotoxic JWA gene activating compound 1 (JAC1) to inhibit …

Label-free quantitative identification of abnormally ubiquitinated proteins as useful biomarkers for human lung squamous cell carcinomas

M Lu, W Chen, W Zhuang, X Zhan - EPMA Journal, 2020 - Springer
Background Ubiquitination is an important molecular event in lung squamous cell carcinoma
(LSCC), which currently is mainly studied in nonsmall cell lung carcinoma cell models but …

Butyrophilin-like 9 expression is associated with outcome in lung adenocarcinoma

W Ma, J Liang, J Mo, S Zhang, N Hu, D Tian, Z Chen - BMC cancer, 2021 - Springer
Background Lung adenocarcinoma (LUAD) is the most prevalent non-small cell lung cancer
(NSCLC). Patients with LUAD have a poor 5-year survival rate. The use of immune …

SYVN1‐mediated ubiquitination and degradation of MSH3 promotes the apoptosis of lens epithelial cells

X Chen, G Zhang, P Li, J Yu, L Kang, B Qin… - The FEBS …, 2022 - Wiley Online Library
The pathology of age‐related cataract (ARC) mainly involves the misfolding and
aggregation of proteins, especially oxidative damage repair proteins, in the lens, induced by …

NEDD4 negatively regulates GITR via ubiquitination in immune microenvironment of melanoma

Y Guo, L Yang, S Lei, W Tan, J Long - OncoTargets and therapy, 2019 - Taylor & Francis
Introduction Melanoma is a common skin cancer that is usually associated with poor clinical
outcomes. Recently, the immune checkpoint GITR has been identified as a promising target …

[HTML][HTML] TRIM28 is a distinct prognostic biomarker that worsens the tumor immune microenvironment in lung adenocarcinoma

J Liu, X Han, L Chen, D Han, X Mu, X Hu, H Wu… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
The tumor immune microenvironment (TIME) is an important determinant of cancer
prognosis and treatment efficacy. To identify immune-related prognostic biomarkers of lung …

RNF115-mediated ubiquitination of p53 regulates lung adenocarcinoma proliferation

Z Luo, X Ye, F Shou, Y Cheng, F Li, G Wang - Biochemical and Biophysical …, 2020 - Elsevier
Lung adenocarcinoma (LAC) represents approximately 40% of all lung cancer cases and is
the leading cause of cancer-associated mortality worldwide. Although combined treatment …

Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma

M Zheng, Z Ai, Y Guo, Y Chen, P Xie, W An - Oncogene, 2023 - nature.com
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer.
Accumulating evidence indicates that non-alcoholic steatohepatitis (NASH) is a key …

circRNA_0067717 promotes paclitaxel resistance in nasopharyngeal carcinoma by acting as a scaffold for TRIM41 and p53

Y Cheng, Y Zhu, M Xiao, Y Zhang, Z Wang, H Chen… - Cellular Oncology, 2023 - Springer
Abstract Purpose Circular RNAs (circRNAs) play important roles in tumour progression. This
study aimed to explore the mechanism of hsa_circ_0067717 (termed circRNA_0067717) …