Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Cholesterol levels are an initiating risk factor for atherosclerosis. Many genes play a central
role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK …

Blood-brain barrier (BBB) damage can be a result of central nervous system (CNS) diseases
and may be a cause of CNS deterioration. However, there are still many unknowns …

Osteoarthritis (OA) is a degenerative joint disorder causing pain and functional disability.
Emerging evidence reveals that circular RNAs (circRNAs) play essential roles in OA …

Nonalcoholic fatty liver disease (NAFLD), or, more accurately, metabolic associated fatty
liver disease, accounts for a large proportion of chronic liver disorders worldwide and is …

Liver disease has become a major health problem worldwide due to its high morbidity and
mortality. In recent years, a large body of literature has shown that mesenchymal stem cell …

Hepatocellular carcinoma (HCC) is the main histologic type of liver cancer. It accounts for
the majority of all diagnoses and deaths due to liver cancer. The induction of tumor cell …

Circular RNA (circRNA) is a type of non-coding RNA characterized by a covalently closed
continuous loop. CircRNA is generated by pre-mRNA through back-splicing and is probably …

Resmetirom, a liver-directed, orally active agonist of THR-β, could play a favorable role in
treating NASH, but little is known about the underlying mechanism. A NASH cell model was …

This study presents a liquid metal electrodynamic accumulation microfluidic (LEAM) device
that effectively controls DNA dynamics using liquid metal (LM) electrodes and an applied …