COVID-19 vaccine development: milestones, lessons and prospects
M Li, H Wang, L Tian, Z Pang, Q Yang… - Signal transduction and …, 2022 - nature.com
With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern
(VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 …
(VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 …
The germinal centre B cell response to SARS-CoV-2
BJ Laidlaw, AH Ellebedy - Nature Reviews Immunology, 2022 - nature.com
The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …
cells and memory B cells capable of mediating long-term protective immunity …
[HTML][HTML] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination
SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen …
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen …
SARS-CoV-2-specific T cells in infection and vaccination
During viral infections, antibodies and T cells act together to prevent pathogen spread and
remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger …
remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger …
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells
Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high,
variant emergence has prompted booster immunizations. However, the effects of repeated …
variant emergence has prompted booster immunizations. However, the effects of repeated …
Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection
T cells are a critical component of the response to SARS-CoV-2, but their kinetics after
infection and vaccination are insufficiently understood. Using" spheromer" peptide-MHC …
infection and vaccination are insufficiently understood. Using" spheromer" peptide-MHC …
COVID-19 vaccination in pregnancy, paediatrics, immunocompromised patients, and persons with history of allergy or prior SARS-CoV-2 infection: overview of current …
To date, four vaccines have been authorised for emergency use and under conditional
approval by the European Medicines Agency to prevent COVID-19: Comirnaty, COVID-19 …
approval by the European Medicines Agency to prevent COVID-19: Comirnaty, COVID-19 …
[HTML][HTML] T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre …
Background Previous infection with SARS-CoV-2 affects the immune response to the first
dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and …
dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and …
BA. 2 and BA. 5 omicron differ immunologically from both BA. 1 omicron and pre-omicron variants
Several studies have shown that SARS-CoV-2 BA. 1 omicron is an immune escape variant.
Meanwhile, however, omicron BA. 2 and BA. 5 became dominant in many countries and …
Meanwhile, however, omicron BA. 2 and BA. 5 became dominant in many countries and …
Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history
P Kiszel, P Sík, J Miklós, E Kajdácsi, G Sinkovits… - Scientific Reports, 2023 - nature.com
Vaccinations against SARS-CoV-2 reduce the risk of developing serious COVID-19 disease.
Monitoring spike-specific IgG subclass levels after vaccinations may provide additional …
Monitoring spike-specific IgG subclass levels after vaccinations may provide additional …