TDP-43 Epigenetic Facets and Their Neurodegenerative Implications

J Gimenez, A Spalloni, S Cappelli, F Ciaiola… - International journal of …, 2023 - mdpi.com
Since its initial involvement in numerous neurodegenerative pathologies in 2006, either as a
principal actor or as a cofactor, new pathologies implicating transactive response (TAR) …

Current understanding of complement proteins as therapeutic targets for the treatment of immunoglobulin a nephropathy

A Rajasekaran, TJ Green, MB Renfrow, BA Julian… - Drugs, 2023 - Springer
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide and a frequent cause of kidney failure. Currently, the diagnosis necessitates a …

Steps to improve precision medicine in epilepsy

S Balestrini, D Mei, SM Sisodiya, R Guerrini - Molecular Diagnosis & …, 2023 - Springer
Precision medicine is an old concept, but it is not widely applied across human health
conditions as yet. Numerous attempts have been made to apply precision medicine in …

Advanced Omics Techniques for Understanding Cochlear Genome, Epigenome, and Transcriptome in Health and Disease

A Tisi, S Palaniappan, M Maccarrone - Biomolecules, 2023 - mdpi.com
Advanced genomics, transcriptomics, and epigenomics techniques are providing
unprecedented insights into the understanding of the molecular underpinnings of the central …

RevGel-seq: instrument-free single-cell RNA sequencing using a reversible hydrogel for cell-specific barcoding

J Komatsu, A Cico, R Poncin, M Le Bohec, J Morf… - Scientific Reports, 2023 - nature.com
Progress in sample preparation for scRNA-seq is reported based on RevGel-seq, a
reversible-hydrogel technology optimized for samples of fresh cells. Complexes of one cell …

Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research

R Van Amerongen, M Bentires-Alj… - Journal of mammary …, 2023 - Springer
On 8 December 2022 the organizing committee of the European Network for Breast
Development and Cancer labs (ENBDC) held its fifth annual Think Tank meeting in …

Opportunities and Challenges in Advancing Plant Research with Single-cell Omics

MS Rhaman, M Ali, W Ye, B Li - Genomics, Proteomics & …, 2024 - academic.oup.com
Plants possess diverse cell types and intricate regulatory mechanisms to adapt to the ever-
changing environment of nature. Various strategies have been employed to study cell types …

Multiomics approach towards characterization of tumor cell plasticity and its significance in precision and personalized medicine

MA Aziz - Cancer and Metastasis Reviews, 2024 - Springer
Cellular plasticity refers to the ability of cells to change their identity or behavior, which can
be advantageous in some cases (eg, tissue regeneration) but detrimental in others (eg …

A review of the role of epigenetic studies for intramuscular fat deposition in beef cattle

BK Abebe, J Wang, Y Guo, H Wang, A Li, L Zan - Gene, 2024 - Elsevier
Intramuscular fat (IMF) deposition profoundly influences meat quality and economic value in
beef cattle production. Meanwhile, contemporary developments in epigenetics have opened …

Dissecting the Immune System through Gene Regulation

H Yoshida - Basic Immunology and Its Clinical Application, 2024 - Springer
The immune system plays a dual role in human health, functioning both as a protector
against pathogens and, at times, as a contributor to disease. This feature emphasizes the …