Human intestinal organoids: promise and challenge

J Taelman, M Diaz, J Guiu - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The study of human intestinal biology in healthy and diseased conditions has always been
challenging. Primary obstacles have included limited tissue accessibility, inadequate in vitro …

Non-alcoholic fatty liver disease and gut microbial dysbiosis-underlying mechanisms and gut microbiota mediated treatment strategies

M Jayachandran, S Qu - Reviews in Endocrine and Metabolic Disorders, 2023 - Springer
Non-alcoholic fatty liver disease (NAFLD) is by far the most prevalent form of liver disease
worldwide. It's also the leading cause of liver-related hospitalizations and deaths …

Effects of four food hydrocolloids on colitis and their regulatory effect on gut microbiota

S Zhang, Y Sun, Q Nie, J Hu, Y Li, Z Shi, H Ji… - Carbohydrate …, 2024 - Elsevier
Hydrocolloids are important food additives and have potential regulatory effects on gut
microbiota. The development of colitis is closely related to changes in gut microbiota. The …

[HTML][HTML] Intestinal epithelium in early life

LC Frazer, M Good - Mucosal immunology, 2022 - Elsevier
Rapid development of the fetal and neonatal intestine is required to meet the growth
requirements of early life and form a protective barrier against external insults encountered …

Ellagic acid alleviates oxidative stress by mediating Nrf2 signaling pathways and protects against paraquat-induced intestinal injury in piglets

Y Xiao, R Huang, N Wang, Y Deng, B Tan, Y Yin, M Qi… - Antioxidants, 2022 - mdpi.com
The gastrointestinal tract is a key source of superoxide so as to be one of the most
vulnerable to oxidative stress damage. Ellagic acid (EA), a polyphenol displays widely …

Bacteroides methylmalonyl-CoA mutase produces propionate that promotes intestinal goblet cell differentiation and homeostasis

X Wang, Z Cai, Q Wang, C Wu, Y Sun, Z Wang, X Xu… - Cell Host & Microbe, 2024 - cell.com
Propionate is a short-chain fatty acid that is generated upon microbiome-mediated fiber
fermentation in the intestine. By modulating immune and metabolic pathways, propionate …

Enhanced immune responses to mucosa by functionalized chitosan-based composite nanoparticles as a vaccine adjuvant for intranasal delivery

Y Lin, B Sun, Z Jin, K Zhao - ACS Applied Materials & Interfaces, 2022 - ACS Publications
Nasal administration for vaccine delivery is a novel non-invasive vaccine administration
approach that can induce local or systemic immune responses and overcome the …

Secretory immunoglobulin a immunity in chronic obstructive respiratory diseases

C de Fays, FM Carlier, S Gohy, C Pilette - Cells, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct
respiratory diseases that share features such as the obstruction of small airways and …

Rosmarinic acid restores colonic mucus secretion in colitis mice by regulating gut microbiota-derived metabolites and the activation of inflammasomes

Q Wang, K Xu, X Cai, C Wang, Y Cao… - Journal of Agricultural …, 2023 - ACS Publications
Maintaining a steady state of mucus barrier is an important potential target for polyphenol to
exert its anticolitis activity. This study elucidates the pivotal role of polyphenol rosmaric acid …

Detecting Intestinal Goblet Cells of the Broadgilled Hagfish Eptatretus cirrhatus (Forster, 1801): A Confocal Microscopy Evaluation

A Alesci, S Pergolizzi, S Savoca, A Fumia, A Mangano… - Biology, 2022 - mdpi.com
Simple Summary The intestinal epithelium of fish, similar to mammals, consists mainly of
enterocytes and goblet cells. Goblet cells play a key role in the secretion of mucus, which, in …