More than meets the eye: The role of microglia in healthy and diseased retina

E Murenu, MJ Gerhardt, M Biel… - Frontiers in …, 2022 - frontiersin.org
Microglia are the main resident immune cells of the nervous system and as such they are
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …

A Fish Eye View: Retinal Morphogenesis from Optic Cup to Neuronal Lamination

C Norden - Annual Review of Cell and Developmental Biology, 2023 - annualreviews.org
The neural retina, at the back of the eye, is a fascinating system to use to discover how cells
form tissues in the context of the developing nervous system. The retina is the tissue …

Spatial organization of the mouse retina at single cell resolution by MERFISH

J Choi, J Li, S Ferdous, Q Liang, JR Moffitt… - nature …, 2023 - nature.com
The visual signal processing in the retina requires the precise organization of diverse
neuronal types working in concert. While single-cell omics studies have identified more than …

[HTML][HTML] Multimodal spatiotemporal phenotyping of human retinal organoid development

P Wahle, G Brancati, C Harmel, Z He, G Gut… - Nature …, 2023 - nature.com
Organoids generated from human pluripotent stem cells provide experimental systems to
study development and disease, but quantitative measurements across different spatial …

Neuronal migration prevents spatial competition in retinal morphogenesis

M Rocha-Martins, E Nerli, J Kretzschmar, M Weigert… - Nature, 2023 - nature.com
The concomitant occurrence of tissue growth and organization is a hallmark of organismal
development,–. This often means that proliferating and differentiating cells are found at the …

Cellular migration into a subretinal honeycomb-shaped prosthesis for high-resolution prosthetic vision

MB Bhuckory, BY Wang, ZC Chen… - Proceedings of the …, 2023 - National Acad Sciences
In patients blinded by geographic atrophy, a subretinal photovoltaic implant with 100 µm
pixels provided visual acuity closely matching the pixel pitch. However, such flat bipolar …

[HTML][HTML] Evaluation of the influences of low dose polybrominated diphenyl ethers exposure on human early retinal development

M Li, Y Zeng, L Ge, J Gong, C Weng, C Yang… - Environment …, 2022 - Elsevier
Increasing evidence in animal models has suggested that polybrominated diphenyl ethers
(PBDEs), a class of brominated flame retardants, can cause retinotoxicity. However, data on …

Disorganization of retinal inner layers (DRIL) and neuroretinal dysfunction in early diabetic retinopathy

KA Joltikov, CA Sesi, VM de Castro… - … & visual science, 2018 - iovs.arvojournals.org
Purpose: To elucidate the relationship between disorganization of retinal inner layers
(DRILs) and retinal function in diabetic patients without diabetic retinopathy (DR) and with …

Structural and developmental principles of neuropil assembly in C. elegans

MW Moyle, KM Barnes, M Kuchroo, A Gonopolskiy… - Nature, 2021 - nature.com
Neuropil is a fundamental form of tissue organization within the brain, in which densely
packed neurons synaptically interconnect into precise circuit architecture,. However, the …

Cell type diversity in a developing octopus brain

R Styfhals, G Zolotarov, G Hulselmans… - Nature …, 2022 - nature.com
Octopuses are mollusks that have evolved intricate neural systems comparable with
vertebrates in terms of cell number, complexity and size. The brain cell types that control …