Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease that
affects children and adolescents as well as adults. The etiology has not been established …

The concept that disease rooted principally in chronic aberrant constitutive and reactive
activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged …

In recent years, an association between hypermobile Ehlers-Danlos syndrome (hEDS), mast
cell activation syndrome (MCAS), and postural orthostatic tachycardia syndrome (POTS) has …

Well known for their role in allergic disorders, mast cells (MCs) play a key role in
homeostatic mechanisms and surveillance, recognizing and responding to different …

Mast cell (MC) disease has long been thought to be just the rare disease of mastocytosis (in
various forms, principally cutaneous and systemic), with aberrant MC mediator release at …

Neurologists and psychiatrists frequently encounter patients whose central and/or peripheral
neurologic and/or psychiatric symptoms (NPS) are accompanied by other symptoms for …

As recognition of mast cell (MC) involvement in a range of chronic inflammatory disorders
has increased, diagnosticians' suspicions of MC activation disease (MCAD) in their …

Clonal mast cell disorders comprise a heterogeneous group of disorders characterized by
the presence of gain of function KIT mutations and a constitutively altered activation …

Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in
allergic patients Page 1 Advances in Dermatology and Allergology 5, October / 2019 538 …

Dyspareunia, vaginitis and dysfunctional uterine bleeding (DUB) are common problems
which, despite their polygenicity, commonly appear idiopathic and treatment-refractory. Mast …