SWITCH deficient SUCROSE NONFERMENTING (SWI/SNF) class chromatin remodeling
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

DNA sequencing-based studies of neurodevelopmental disorders (NDDs) have identified a
wide range of genetic determinants. However, a comprehensive analysis of these data, in …

Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear
protein content. The prevailing dogma is that IDRs engage in non-specific interactions …

Abstract Cancer-associated, loss-of-function mutations in genes encoding subunits of the
BRG1/BRM-associated factor (BAF) chromatin-remodeling complexes,,,,,,–often cause …

DNA wraps around the histone octamer to form nucleosomes, the repeating unit of
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …

Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that
regulate genomic architecture. Here, we present a structural model of the endogenously …

Mammalian SWI/SNF (mSWI/SNF) adenosine triphosphate–dependent chromatin
remodelers modulate genomic architecture and gene expression and are frequently mutated …

The recent torrent of structures of chromatin complexes determined by cryoelectron
microscopy provides an opportunity to discern general principles for how chromatin factors …

Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …