An optimal control problem for combination of cancer chemotherapy with immunotherapy in
form of a boost to the immune system is considered as a multi-input optimal control problem …

Cancer immunotherapy aims at eliciting an immune system response against the tumor.
However, it is often characterized by toxic side-effects. Limiting the tumor growth and …

Combined therapy made of a chemotherapy and antiangiogenic agents is a clinical
treatment recommended for its efficiency. Since the optimization of a treatment against …

Human cancers display intra-tumor heterogeneity in many phenotypic features, such as
expression of cell surface receptors, growth, and angiogenic, proliferative, and immunogenic …

Viruses that infect bacteria, ie, bacteriophage or 'phage,'are increasingly considered as
treatment options for the control and clearance of bacterial infections, particularly as …

The cancer stem cell hypothesis states that tumors are heterogeneous and comprised of
several different cell types that have a range of reproductive potentials. Cancer stem cells …

Using one of the well known mathematical models for immunotherapy of tumor–immune
interactions, in this paper an algorithm is developed to optimize the immunotherapy in …

Cancer is a complex, multifaceted disease. Cellular systems are perturbed both during the
onset and development of cancer, and the behavioural change of tumour cells usually …

Autoimmune myocarditis is a rare, but frequently fatal, side effect of immune checkpoint
inhibitors (ICIs), a class of cancer therapies. Despite extensive experimental work on the …

Vaccines represent a special class of drugs, capable of stimulating immune system
responses against pathogens and tumors. Vaccine development is a lengthy process that …