Epilepsy is the tendency to have unprovoked epileptic seizures. Anything causing structural
or functional derangement of brain physiology may lead to seizures, and different conditions …

Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …

Epilepsy is a brain disease associated with epileptic seizures as well as with
neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a …

Approximately 50 million people have epilepsy, making it the most common chronic and
severe neurological disease worldwide, with increased risk of mortality and psychological …

This study tested the hypothesis that acquired epileptogenesis is accompanied by DNA
methylation changes independent of etiology. We investigated DNA methylation and gene …

This article highlights the emerging therapeutic potential of specific epigenetic modulators
as promising antiepileptogenic or disease-modifying agents for curing epilepsy. Currently …

Prevention of epilepsy and its progression remains the most urgent need for epilepsy
research and therapy development. Novel conceptual advances are required to …

Gene and protein expressions display circadian oscillations, which can be disrupted in
diseases in most body organs. Whether these oscillations occur in the healthy hippocampus …

Introduction: In the epilepsy therapeutic arena, there is urgent need for developing novel
antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the …