Schizophrenia is a neurodevelopmental disorder with genetic and environmental factors
involved in its aetiology. Genetic liability contributing to the development of schizophrenia is …

Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …

The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic
architecture of human traits, including the genetic architecture of complex neuropsychiatric …

Background: Ischemic stroke is a highly complex disorder. This study aims to identify novel
methylation changes in ischemic stroke. Methods: We carried out an epigenome-wide study …

Background Language plays a major role in human behavior. For this reason,
neurodevelopmental and psychiatric disorders in which linguistic ability is impaired could …

Broad-based cognitive deficits are an enduring and disabling symptom for many patients
with severe mental illness, and these impairments are inadequately addressed by current …

Objective SETD1A encodes a histone methyltransferase involved in various cell cycle
regulatory processes. Loss-of-function SETD1A variants have been associated with …

Objective Microdeletions are associated with different forms of epilepsy but show incomplete
penetrance, which is not well understood. We aimed to assess whether unmasked variants …

SETD1A has been identified as a substantial risk gene for schizophrenia. To further
investigate the role of SETD1A in the genetic etiology of schizophrenia in the Japanese …

Nearly two hundred common-variant depression risk loci have been identified by genome-
wide association studies (GWAS)–. However, the impact of rare coding variants on …