Molnupiravir: A versatile prodrug against SARS-CoV-2 variants

D Teli, P Balar, K Patel, A Sharma, V Chavda, L Vora - Metabolites, 2023 - mdpi.com
The nucleoside analog β-DN 4-hydroxycytidine is the active metabolite of the prodrug
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …

A review of inactivated COVID-19 vaccine development in China: focusing on safety and efficacy in special populations

L Hu, J Sun, Y Wang, D Tan, Z Cao, L Gao, Y Guan… - Vaccines, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has been widespread globally, and …

Global landscape of COVID-19 research: a visualization analysis of randomized clinical trials

SH Zyoud - Clinical and Experimental Medicine, 2024 - Springer
The emergence of COVID-19 in 2019 has resulted in a significant global health crisis.
Consequently, extensive research was published to understand and mitigate the disease. In …

The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An …

A Sinopoli, A Sciurti, C Isonne, MM Santoro… - Nutrients, 2024 - mdpi.com
This review aims to evaluate the efficacy of any vitamin administration (s) in preventing and
managing COVID-19 and/or long-COVID. Databases were searched up to May 2023 to …

A review of hematological complications and treatment in COVID-19

AN Yazdani, A Abdi, P Velpuri, P Patel, N DeMarco… - Hematology …, 2023 - mdpi.com
COVID-19, caused by SARS-CoV-2, and its variants have spread rapidly across the globe in
the past few years, resulting in millions of deaths worldwide. Hematological diseases and …

A clinical insight on new discovered molecules and repurposed drugs for the treatment of COVID-19

S Banerjee, D Banerjee, A Singh, S Kumar, D Pooja… - Vaccines, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began churning out
incredulous terror in December 2019. Within several months from its first detection in …

Antiviral activity of molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and its therapeutic window in a human lung cell model

T Prince, I Donovan-Banfield, H Goldswain… - bioRxiv, 2021 - biorxiv.org
Synopsis Background The UK Medicines and Regulatory Healthcare Agency (MHRA) have
recently licensed the anti-viral drug, molnupiravir, for use in patients with mild-moderate …

A plausible hypothesis for the higher Covid-19 mortality in Brazil

SH Machado - African Health Sciences, 2023 - ajol.info
Brazil has high Covid-19 mortality rates, especially among those patients who are intubated.
It is hypothetically considered that these rates may be related to the abusive use of …

Efficacy and safety of casirivimab-imdevimab combination on COVID-19 patients: A systematic review and meta-analysis randomized controlled trial

IA Wicaksono, C Suhandi, KM Elamin, N Wathoni - Heliyon, 2023 - cell.com
Background The advantages and disadvantages of casirivimab-imdevimab for coronavirus
disease 2019 are not well understood. We conducted a systematic review and meta …

Population Pharmacokinetics of Nirmatrelvir in Chinese Patients with COVID-19: Therapeutic Drug Monitoring and Dosing Regimen Selection in Clinical Practice

P Yang, W Liu, Y Ying, L Zhao, X Xiong, X Zhang… - International Journal of …, 2024 - Elsevier
ABSTRACT OBJECTIVES To establish a population pharmacokinetics (PopPK) model of
nirmatrelvir in Chinese COVID-19 patients and provide reference for refining the dosing …