Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …

T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

Immunotherapy with immune-checkpoint inhibitors (ICIs) and targeted therapy with BRAF
and MEK inhibitors have revolutionized the treatment of melanoma over the past decade …

Neoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for
treating cancer. The recognition of antigens by immune cells is a crucial step in tumor …

The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Human papillomaviruses (HPVs) are the causative agent of several anogenital cancers as
well as head and neck cancers, with HPV+ head and neck squamous cell carcinoma …

Background Tumor vaccines have become crucial in cancer immunotherapy, but, only a
limited number of phase III clinical trials have demonstrated clinical efficacy. The crux of this …

Immunotherapies have revolutionized cancer treatment approaches. Because not all
patients respond positively to immune therapeutic agents, it represents a challenge for …

Motivation The interactions between T-cell receptors (TCR) and peptide-major
histocompatibility complex (pMHC) are essential for the adaptive immune system. However …