[HTML][HTML] The anti-inflammatory effects of itaconate and its derivatives in neurological disorders
X Kong, L Xu, Z Mou, W Lyu, K Shan, L Wang… - Cytokine & Growth …, 2024 - Elsevier
Almost 16% of the global population is affected by neurological disorders, including
neurodegenerative and cerebral neuroimmune diseases, triggered by acute or chronic …
neurodegenerative and cerebral neuroimmune diseases, triggered by acute or chronic …
Tricarboxylic Acid Cycle Regulation of Metabolic Program, Redox System, and Epigenetic Remodeling for Bone Health and Disease
WS Lian, RW Wu, YH Lin, YS Chen, H Jahr, FS Wang - Antioxidants, 2024 - mdpi.com
Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates
the development of osteoporosis, which is the leading risk factor of disability in the elderly …
the development of osteoporosis, which is the leading risk factor of disability in the elderly …
In vivo single-cell high-dimensional mass cytometry analysis to track the interactions between Klebsiella pneumoniae and myeloid cells
R Calderon-Gonzalez, A Dumigan, J Sá-Pessoa… - PLoS …, 2024 - journals.plos.org
In vivo single-cell approaches have transformed our understanding of the immune
populations in tissues. Mass cytometry (CyTOF), that combines the resolution of mass …
populations in tissues. Mass cytometry (CyTOF), that combines the resolution of mass …
Multifaceted mitochondria in innate immunity
E Marques, R Kramer, DG Ryan - npj Metabolic Health and Disease, 2024 - nature.com
The ability of mitochondria to transform the energy we obtain from food into cell
phosphorylation potential has long been appreciated. However, recent decades have seen …
phosphorylation potential has long been appreciated. However, recent decades have seen …
Itaconate as a potential target for antimalarial therapy
JP Bernardi, TJ Nappi, NS Butler - Trends in Parasitology, 2024 - cell.com
In a recent publication, Ramalho et al. investigated monocyte-derived dendritic cell (MODC)
mobilization in response to Plasmodium infection. The authors showed that elevated levels …
mobilization in response to Plasmodium infection. The authors showed that elevated levels …
Itaconate boosts malaria via induction of PD-L1
Y Min, LAJ O'Neill - Cell Metabolism, 2024 - Elsevier
The Krebs-cycle-derived metabolite itaconate has been shown to be immunomodulatory,
targeting multiple processes in macrophages. Ramalho et al. reveal an additional role for …
targeting multiple processes in macrophages. Ramalho et al. reveal an additional role for …