Chronic activation of the renin‐angiotensin‐aldosterone system (RAAS) promotes and
perpetuates the syndromes of congestive heart failure, systemic hypertension, and chronic …

Concerns have been raised regarding the safety of angiotensin converting enzyme
inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in patients with coronavirus …

Evidence about the association between treatment with high–risk medicines and frailty in
older individuals is limited. We investigated the relationship between high–risk prescribing …

Animal microRNAs (miRNAs) regulate gene expression through base pairing to their targets
within the 3′ untranslated region (UTR) of protein-coding genes. Single-nucleotide …

OBJECTIVE—Angiotensin II has been shown to increase hepatic glucose production and
decrease insulin sensitivity. Patients who utilize either an ACE inhibitor (ACEI) or …

Drug discovery and development is a high-risk enterprise that requires significant
investments in capital, time and scientific expertise. The studies of xenobiotic metabolism …

In the present study, whey protein concentrate (WPC-80) and β-lactoglobulin were
hydrolyzed with a noncommercial serine protease isolated from Asian pumpkin (Cucurbita …

Abstract Background and Aims Haemodynamic instability is associated with peri-operative
myocardial injury, particularly in patients receiving renin–angiotensin system (RAS) …

Reactive oxygen species (ROS) are molecules involved in signal transduction pathways
with both beneficial and detrimental effects on human cells. ROS are generated by many …

Carboxylic acids are often present as a functional group of effective medicines. They are
involved in specific charge-charge interactions and are thus often critical for the binding of …