International efforts in developing a vaccine against Chlamydia trachomatis have
highlighted the need for novel immunization strategies for the induction of genital immunity …

Characterizing the impact of the vaccination schedule on the induction of B and T cell
immune responses is critical for improving vaccine immunogenicity. Here we compare the …

Infections with Streptococcus pyogenes and their sequelae are responsible for an estimated
18 million cases of serious disease with> 700 million new primary cases and 500,000 …

The development of new adjuvants enables fine modulation of the elicited immune
responses. Ideally, the use of one or more adjuvants should result in the induction of a …

The emergence of rapidly spreading variants of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) poses a major challenge to vaccines' protective efficacy …

The selection of any specific immunization route is critical when defining future vaccine
strategies against a genital infection like Chlamydia trachomatis (Ct). An optimal Chlamydia …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccine-induced systemic antibody profiles are well characterized; however, little is known …

The efficacy of vaccine adjuvants depends on their ability to appropriately enhance the
immunogenicity of vaccine antigens, which is often insufficient in non-adjuvanted vaccines …

Transcriptomic profiling of the immune response induced by vaccine adjuvants is of critical
importance for the rational design of vaccination strategies. In this study, transcriptomics was …

Cocaine is one of the most potent and addictive psychostimulants known and there are no
available pharmacotherapies to treat cocaine addiction. Here we describe a novel cocaine …