The Key to Increase Immunogenicity of Next‐Generation COVID‐19 Vaccines Lies in the Inclusion of the SARS‐CoV‐2 Nucleocapsid Protein

NJ Mendoza-Ramírez, J García-Cordero… - Journal of …, 2024 - Wiley Online Library
Vaccination is one of the most effective prophylactic public health interventions for the
prevention of infectious diseases such as coronavirus disease (COVID‐19). Considering the …

Single MVA-SARS-2-ST/N vaccination rapidly protects K18-hACE2 mice against a lethal SARS-CoV-2 challenge infection

S Clever, L Limpinsel, C Meyer zu Natrup… - Viruses, 2024 - mdpi.com
The sudden emergence of SARS-CoV-2 demonstrates the need for new vaccines that
rapidly protect in the case of an emergency. In this study, we developed a recombinant MVA …

Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform

M Yll-Pico, Y Park, J Martinez, A Iniguez, M Kha, T Kim… - npj Vaccines, 2024 - nature.com
Human cytomegalovirus (CMV) is the most common infectious cause of complications post-
transplantation, while a CMV vaccine for transplant recipients has yet to be licensed. Triplex …

Rendezvous with Vaccinia Virus in the Post-smallpox Era: R&D Advances

Y Wang - Viruses, 2023 - mdpi.com
Smallpox was eradicated in less than 200 years after Edward Jenner's practice of cowpox
variolation in 1796. The forty-three years of us living free of smallpox, beginning in 1979 …

Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus

F Chiuppesi, JA Zaia, MA Gutierrez-Franco… - Communications …, 2024 - nature.com
Background Although the mpox global health emergency caused by mpox virus (MPXV)
clade IIb. 1 has ended, mpox cases are still reported due to low vaccination coverage and …

Preclinical immune efficacy against SARS-CoV-2 beta B. 1.351 variant by MVA-based vaccine candidates

P Pérez, G Albericio, D Astorgano, S Flores… - Frontiers in …, 2023 - frontiersin.org
The constant appearance of new severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants of concern (VoCs) has jeopardized the protective capacity of approved …

Protective MVA-ST Vaccination Robustly Activates T Cells and Antibodies in an Aged-Hamster Model for COVID-19

S Clever, LM Schünemann, F Armando… - Vaccines, 2024 - mdpi.com
Aging is associated with a decline in immune system functionality. So-called
immunosenescence may impair the successful vaccination of elderly people. Thus …

Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic …

F Chiuppesi, S Ortega-Francisco, MA Gutierrez, J Li… - Vaccines, 2023 - mdpi.com
Hematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR)-T cell
patients are immunocompromised, remain at high risk following SARS-CoV-2 infection, and …

[HTML][HTML] Intranasal inoculation of female BALB/c mice with replication-deficient human adenovirus type 5 expressing SARS-CoV‐2 nucleocapsid protein aggravates …

J Cao, H Gu, X Zhang, H Yun, J Li, CY Si, J Zhang… - Virus Research, 2023 - Elsevier
Preclinical studies indicate that SARS-CoV-2 nucleocapsid (N)-based vaccines, along with
other viral protein (s), confer protection in various animal models against infection by SARS …