The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

The nuclear events of a eukaryotic cell, such as replication, transcription, recombination and
repair etc. require the transition of the compactly arranged chromatin into an uncompacted …

Cardiovascular diseases have been closely linked to abnormal epigenetic regulation. In the
context of epigenetic regulation, BRG1, a pivotal SWI/SNF chromatin remodeling enzyme …

Mature vascular smooth muscle cells (VSMC) exhibit a remarkable degree of plasticity, a
characteristic that has intrigued cardiovascular researchers for decades. Recently, it has …

The understanding of the mechanisms that regulate gene expression to establish
differentiation programs and determine cell lineages, is one of the major challenges in …

We construct and analyze monomeric and multimeric models of the stochastic disassembly
of a single nucleosome. Our monomeric model predicts the time needed for a number of …

The SWI/SNF complex, also known as the BRG1/BRM-associated factor (BAF) complex,
represents a critical regulator of chromatin remodeling mechanisms in mammals. It is …

SWI/SNF protein complexes are evolutionarily conserved epigenetic regulators described in
all eukaryotes. In metameric animals, the complexes are involved in all processes occurring …

Alternative transcription start sites can affect transcript isoform diversity and translation
levels. In a recently described form of gene regulation, coordinated transcriptional and …

The cell nucleus plays a critical role in cell migration by its deformability under forces, by
acting as a piston that activates mechanosensitive channels, and also by serving as a ruler …