Binding of the thyroid hormone receptor (TR) to thyroid hormone-responsive elements
(TREs) is crucial for regulation of gene expression by thyroid hormone. The TR binds to …

Thyroid hormones (THs) are powerful regulators of metabolism with major effects on body
weight, cholesterol, and liver fat that have been exploited pharmacologically for many years …

Background: Thyroid hormone (TH) action is mediated by three major thyroid hormone
receptor (THR) isoforms α1, β1, and β2 (THRA1, THRB1, and THRB2). These THRs and a …

The β isoform of thyroid hormone receptor (TR-β) has a key role in the feedback regulation
of the hypothalamic-pituitary-thyroid (HPT) axis. The mechanism of trans-repression of the …

All cranial nerves, as well as the VIIIth nerve which invades the cochlea, have a proximal
end in which myelin is formed by Schwann cells and a distal end which is surrounded by …

Thyroid hormones are essential for correct brain development, and since vertebrates
express two thyroid hormone receptor genes (TR alpha and beta), we investigated TR gene …

A number of studies have provided evidence for a link between thyroid hormones and
physiological or pathophysiological conditions associated with reproduction. Most of the …

We have studied the rat malic enzyme gene as a model for thyroid hormone
(triiodothyronine (T3)) regulation of transcription. Our previous studies showed that …

Thyroid hormones (TH; T3 and T4) play a fundamental role in the fetal stage to the adult
phase, controlling gene and protein expression in virtually all tissues. The endocrine and …

Hypothalamic thyrotropin-releasing hormone (TRH) stimulates thyroid-stimulating hormone
(TSH) secretion from the anterior pituitary. TSH then initiates thyroid hormone (TH) synthesis …