Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

Cardiovascular pathologies are still the primary cause of death worldwide. The molecular
mechanisms behind these pathologies have not been fully elucidated. Unravelling them will …

Background and Purpose—A short duration of ischemia (ie, ischemic preconditioning [PC])
can provide significant brain protection to subsequent ischemic events (ie, ischemic …

GJ Grover and KA Garlid. ATP-Sensitive Potassium Channels: A Review of their
Cardioprotective Pharmacology. Journal of Molecular and Cellular Cardiology (2000) 32 …

Heart tissue is remarkably sensitive to oxygen deprivation. Although heart cells, like those of
most tissues, rapidly adapt to anoxic conditions, relatively short periods of ischaemia and …

The cardiovascular system is a complex and well-organized system in which glycosylation
plays a vital role. The heart and vascular wall cells are constituted by an array of specific …

Complex paracrine interactions exist between endothelial cells and cardiac myocytes in the
heart. Cardiac endothelial cells release (or metabolize) several diffusible agents (eg, nitric …

1. Ischemic preconditioning and its endpoints morphological protection, while on the other
hand caution should be used when extrapolating findings from short-Brief episodes of …

Renal ischemia and reperfusion during aortic and renal transplant surgery result in ischemic-
reperfusion injury. Ischemic preconditioning and adenosine infusion before ischemia protect …

The phosphodiesterase type-5 (PDE5) inhibitor, sildenafil, is the first drug developed for
treatment of erectile dysfunction in patients. Experimental data in animals show that …