Genome-wide association studies (GWAS) have revealed thousands of genetic loci that underpin the complex biology of many human traits. However, the strength of GWAS–the …
NG Skene, SGN Grant - Frontiers in neuroscience, 2016 - frontiersin.org
The cell types that trigger the primary pathology in many brain diseases remain largely unknown. One route to understanding the primary pathological cell type for a particular …
Decreased synaptic spine density has been the most consistently reported postmortem finding in schizophrenia (SCZ). A recently developed in vivo measure of synaptic vesicle …
A Sugathan, M Biagioli, C Golzio… - Proceedings of the …, 2014 - National Acad Sciences
Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum …
V Sytnyk, I Leshchyns'ka, M Schachner - Trends in neurosciences, 2017 - cell.com
Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in vertebrate and invertebrate nervous systems. Prominent family members are the neural cell …
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic and neurobiological background influences early brain development, and whose precise …
P Saftig, SF Lichtenthaler - Progress in neurobiology, 2015 - Elsevier
Proteins belonging to the 'A Disintegrin And Metalloproteinase'(ADAM) family are membrane- anchored proteases that are able to cleave the extracellular domains of several membrane …
F Guan, T Ni, W Zhu, LK Williams, LB Cui, M Li… - Molecular …, 2022 - nature.com
Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and complex inheritance. In the past decade, successful identification of numerous susceptibility …
VK Ramanan, AJ Saykin - American journal of neurodegenerative …, 2013 - ncbi.nlm.nih.gov
The discovery of causative genetic mutations in affected family members has historically dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …