The DNA damage response and inflammation in cancer
Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …
Genetic mechanisms of fertilization failure and early embryonic arrest: a comprehensive review
Y Wei, J Wang, R Qu, W Zhang, Y Tan… - Human …, 2024 - academic.oup.com
BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …
Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells
X Li, Y Zhong, X Zhang, AK Sood, J Liu - Oncogene, 2023 - nature.com
To understand how malignant tumors develop, we tracked cell membrane, nuclear
membrane, spindle, and cell cycle dynamics in polyploid giant cancer cells (PGCCs) during …
membrane, spindle, and cell cycle dynamics in polyploid giant cancer cells (PGCCs) during …
Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss
Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The
prevalence of these abnormalities and the allocation of (ab) normal cells in embryonic and …
prevalence of these abnormalities and the allocation of (ab) normal cells in embryonic and …
Regulation of mammalian totipotency: a molecular perspective from in vivo and in vitro studies
T Nakatani, ME Torres-Padilla - Current Opinion in Genetics & …, 2023 - Elsevier
Highlights•Cellular models can recapitulate some aspects of embryonic genome
activation.•Multiple factors regulate embryonic genome activation.•Several types of totipotent …
activation.•Multiple factors regulate embryonic genome activation.•Several types of totipotent …
Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1
L Moritz, SB Schon, M Rabbani, Y Sheng… - Nature structural & …, 2023 - nature.com
Conventional dogma presumes that protamine-mediated DNA compaction in sperm is
achieved by electrostatic interactions between DNA and the arginine-rich core of …
achieved by electrostatic interactions between DNA and the arginine-rich core of …
The destinies of human embryos reaching blastocyst stage between Day 4 and Day 7 diverge as early as fertilization
G Coticchio, K Ezoe, C Lagalla, C Zacà… - Human …, 2023 - academic.oup.com
STUDY QUESTION What clinical and laboratory differences emerge from parallel direct
comparison of embryos reaching the blastocyst stage between Days 4, 5, 6, and 7 (Days 4 …
comparison of embryos reaching the blastocyst stage between Days 4, 5, 6, and 7 (Days 4 …
Replication stress in mammalian embryo development, differentiation, and reprogramming
Duplicating a genome of 3 billion nucleotides is challenged by a variety of obstacles that can
cause replication stress and affect the integrity of the genome. Recent studies show that …
cause replication stress and affect the integrity of the genome. Recent studies show that …
Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos
RC McCoy, MC Summers, A McCollin, CS Ottolini… - Genome medicine, 2023 - Springer
Background The high incidence of aneuploidy in early human development, arising either
from errors in meiosis or postzygotic mitosis, is the primary cause of pregnancy loss …
from errors in meiosis or postzygotic mitosis, is the primary cause of pregnancy loss …
A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells
Resistance to therapy commonly develops in patients with high-grade serous ovarian
carcinoma (HGSC) and triple-negative breast cancer (TNBC), urging the search for …
carcinoma (HGSC) and triple-negative breast cancer (TNBC), urging the search for …