Targeting STAT3 in cancer immunotherapy
S Zou, Q Tong, B Liu, W Huang, Y Tian, X Fu - Molecular cancer, 2020 - Springer
As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …
Spatial predictors of immunotherapy response in triple-negative breast cancer
Immune checkpoint blockade (ICB) benefits some patients with triple-negative breast
cancer, but what distinguishes responders from non-responders is unclear. Because ICB …
cancer, but what distinguishes responders from non-responders is unclear. Because ICB …
Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions
In the past decades, transcriptomic studies have revolutionized cancer treatment and
diagnosis. However, tumor sequencing strategies typically result in loss of spatial …
diagnosis. However, tumor sequencing strategies typically result in loss of spatial …
TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment
Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows
remarkable efficacy in a variety of cancer types. However, only a minority of patients respond …
remarkable efficacy in a variety of cancer types. However, only a minority of patients respond …
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications
Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …
Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia
ND Anderson, J Birch, T Accogli, I Criado… - Nature Medicine, 2023 - nature.com
In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia
(R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable …
(R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable …
RNA sequencing: new technologies and applications in cancer research
M Hong, S Tao, L Zhang, LT Diao, X Huang… - Journal of hematology & …, 2020 - Springer
Over the past few decades, RNA sequencing has significantly progressed, becoming a
paramount approach for transcriptome profiling. The revolution from bulk RNA sequencing …
paramount approach for transcriptome profiling. The revolution from bulk RNA sequencing …
Interpretation of T cell states from single-cell transcriptomics data using reference atlases
Single-cell RNA sequencing (scRNA-seq) has revealed an unprecedented degree of
immune cell diversity. However, consistent definition of cell subtypes and cell states across …
immune cell diversity. However, consistent definition of cell subtypes and cell states across …
[HTML][HTML] A guide to cancer immunotherapy: from T cell basic science to clinical practice
AD Waldman, JM Fritz, MJ Lenardo - Nature Reviews Immunology, 2020 - nature.com
The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a
central focus for engaging the immune system in the fight against cancer. Basic science …
central focus for engaging the immune system in the fight against cancer. Basic science …
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression
Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-
characterized pathological stages of initiation and progression. However, high-resolution …
characterized pathological stages of initiation and progression. However, high-resolution …