[HTML][HTML] Determining chromatin architecture with Micro Capture-C
Abstract Micro Capture-C (MCC) is a chromatin conformation capture (3C) method for
visualizing reproducible three-dimensional contacts of specified regions of the genome at …
visualizing reproducible three-dimensional contacts of specified regions of the genome at …
[HTML][HTML] Deep learning applications in single-cell genomics and transcriptomics data analysis
Traditional bulk sequencing methods are limited to measuring the average signal in a group
of cells, potentially masking heterogeneity, and rare populations. The single-cell resolution …
of cells, potentially masking heterogeneity, and rare populations. The single-cell resolution …
[HTML][HTML] Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19)
pandemic has caused millions of deaths worldwide. Genome-wide association studies …
pandemic has caused millions of deaths worldwide. Genome-wide association studies …
Defining genome architecture at base-pair resolution
In higher eukaryotes, many genes are regulated by enhancers that are 104–106 base pairs
(bp) away from the promoter. Enhancers contain transcription-factor-binding sites (which are …
(bp) away from the promoter. Enhancers contain transcription-factor-binding sites (which are …
[HTML][HTML] Limited conservation in cross-species comparison of GLK transcription factor binding suggested wide-spread cistrome divergence
Non-coding cis-regulatory variants in animal genomes are an important driving force in the
evolution of transcription regulation and phenotype diversity. However, cistrome dynamics in …
evolution of transcription regulation and phenotype diversity. However, cistrome dynamics in …
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells
Understanding clonal evolution and cancer development requires experimental approaches
for characterizing the consequences of somatic mutations on gene regulation. However, no …
for characterizing the consequences of somatic mutations on gene regulation. However, no …
High-throughput methods for the analysis of transcription factors and chromatin modifications: Low input, single cell and spatial genomic technologies
M Salma, C Andrieu-Soler, V Deleuze… - Blood Cells, Molecules …, 2023 - Elsevier
Genome-wide analysis of transcription factors and epigenomic features is instrumental to
shed light on DNA-templated regulatory processes such as transcription, cellular …
shed light on DNA-templated regulatory processes such as transcription, cellular …
[HTML][HTML] Acetylation of histones and non-histone proteins is not a mere consequence of ongoing transcription
In all eukaryotes, acetylation of histone lysine residues correlates with transcription
activation. Whether histone acetylation is a cause or consequence of transcription is …
activation. Whether histone acetylation is a cause or consequence of transcription is …
[HTML][HTML] MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia
NT Crump, AL Smith, L Godfrey… - Nature …, 2023 - nature.com
Aberrant enhancer activation is a key mechanism driving oncogene expression in many
cancers. While much is known about the regulation of larger chromosome domains in …
cancers. While much is known about the regulation of larger chromosome domains in …
[图书][B] Next-generation sequencing data analysis
X Wang - 2016 - taylorfrancis.com
Next-generation DNA and RNA sequencing has revolutionized biology and medicine. With
sequencing costs continuously dropping and our ability to generate large datasets rising …
sequencing costs continuously dropping and our ability to generate large datasets rising …