The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

The cornea is a specialized, transparent, avascular, immune-privileged, and heavily
innervated tissue that affords 2/3rd of refraction to the eye. Ocular injuries, infections, and …

Tumor-associated macrophages (TAMs) and microglia (MG) are potent regulators of glioma
development and progression. However, the dynamic alterations of distinct TAM populations …

Dendritic cells (DC) are a class of bone‐marrow‐derived cells arising from lympho‐myeloid
haematopoiesis that form an essential interface between the innate sensing of pathogens …

Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

Investigations into the interaction between radiotherapy and the host immune system have
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …

Defining the origins and developmental pathways of tissue-resident macrophages should
help refine our understanding of the role of these cells in various disease settings and …

Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes,
and macrophages. They are highly dynamic, with the capacity to enter skin from the …

Immunotherapy is radically changing the clinical management of patients affected by an
increasingly wide array of tumours. However, not all patients achieve long-term clinical …

Radiotherapy (RT) is currently used in more than 50% of cancer patients during the course
of their disease in the curative, adjuvant or palliative setting. RT achieves good local control …