COVID-19 and Long COVID: disruption of the neurovascular unit, blood-brain barrier, and tight junctions

D Kempuraj, KK Aenlle, J Cohen… - The …, 2023 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …

Diet and lifestyle impact the development and progression of Alzheimer's dementia

S Arora, JA Santiago, M Bernstein… - Frontiers in Nutrition, 2023 - frontiersin.org
Dementia is a growing public health concern, with an estimated prevalence of 57 million
adults worldwide. Alzheimer's disease (AD) accounts for 60–80% of the cases. Clinical trials …

Reactive gliosis in traumatic brain injury: a comprehensive review

Z Amlerova, M Chmelova, M Anderova… - Frontiers in Cellular …, 2024 - frontiersin.org
Traumatic brain injury (TBI) is one of the most common pathological conditions impacting the
central nervous system (CNS). A neurological deficit associated with TBI results from a …

[HTML][HTML] Flavonoids and ischemic stroke-induced neuroinflammation: focus on the glial cells

W Lu, Z Chen, J Wen - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Ischemic stroke is one of the most cases worldwide, with high rate of morbidity and mortality.
In the pathological process of ischemic stroke, neuroinflammation is an essential process …

Myricetin suppresses traumatic brain injury-induced inflammatory response via EGFR/AKT/STAT pathway

C Wang, S Ouyang, X Zhu, Y Jiang, Z Lu, P Gong - Scientific Reports, 2023 - nature.com
Traumatic brain injury (TBI) is a common disease in neurosurgery with a high fatality and
disability rate which imposes a huge burden on society and patient's family. Inhibition of …

The Role of Matrix Metalloproteinases in Hemorrhagic Transformation in the Treatment of Stroke with Tissue Plasminogen Activator

VA Babenko, KS Fedulova, DN Silachev… - Journal of Personalized …, 2023 - mdpi.com
Ischemic stroke is a leading cause of disability and mortality worldwide. The only approved
treatment for ischemic stroke is thrombolytic therapy with tissue plasminogen activator (tPA) …

The effect of Epimedium isopentenyl flavonoids on the broiler gut health using microbiomic and metabolomic analyses

J Zhang, Q Zhao, Y Qin, W Si, H Zhang… - International Journal of …, 2023 - mdpi.com
Epimedium (EM), also known as barrenwort, is a traditional medicinal plant rich in
isopentenyl flavonols, which have beneficial biological activities and can improve human …

A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders

W Niu, Y Feng, M Peng, J Cai - Phytotherapy Research, 2024 - Wiley Online Library
Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by
glucose and lipid metabolism disorders with a complex and diverse etiology and rapidly …

Mechanisms of inflammation after ischemic stroke in brain-peripheral crosstalk

L Xie, M He, C Ying, H Chu - Frontiers in Molecular Neuroscience, 2024 - frontiersin.org
Stroke is a devastating disease with high morbidity, disability, and mortality, among which
ischemic stroke is more common. However, there is still a lack of effective methods to …

Unveiling myricetin's pharmacological potency: A comprehensive exploration of the molecular pathways with special focus on PI3K/AKT and Nrf2 signaling

A Goyal, O Sikarwar, A Verma, K Solanki… - … of Biochemical and …, 2024 - Wiley Online Library
Myricetin can be found in the traditional Chinese medicinal plant, Myrica rubra. Myricetin is a
flavonoid that is present in many vegetables, fruits, and plants and is considered to have …