Neuroinflammation contributes to Alzheimer's disease (AD) progression. Secondary
inflammatory insults trigger delirium and can accelerate cognitive decline. Individual cellular …

Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …

Abstract Cucurbitacin B (CuB, C 32 H 46 O 8), the most abundant and active member of
cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely …

Abstract Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …

Epidemiological studies have shown a clear association between maternal infection and
schizophrenia or autism in the progeny. Animal models have revealed maternal immune …

Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of
death in the US. The neuropathological hallmarks of the disease are extracellular amyloid-β …

The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …

Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

Major depressive disorder (MDD) is a common emotional cognitive disorder that seriously
affects people's physical and mental health and their quality of life. Due to its clinical and …

Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …