Several signaling pathways are activated by all-trans-retinoic acid (RA) to mediate induction
of differentiation and apoptosis of malignant cells. In the present study we provide evidence …

Acute promyelocytic leukemia is a form of acute myelogenous leukemia, characterized by
the t (15; 17) chromososmal translocation and the presence of the abnormal PML-RAR α …

Type 1 diabetes (T1D) is an autoimmune disease that shows familial aggregation in humans
and likely has genetic determinants. Disease linkage studies have revealed many …

OBJECTIVE: The standard of care for promyelocytic leukemia includes use of the
differentiating agent all-trans retinoic acid (RA) and chemotherapy. RA induces cell …

6-Formylindolo (3, 2-b) carbazole (FICZ) is a photoproduct of tryptophan and an
endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was previously …

MAPK signaling is required for retinoic acid (RA)-triggered G 0 cell cycle arrest and cell
differentiation, but the mechanism is not well defined. In this study, RA is found to cause …

Retinoic acid (RA)-elicited signaling has been shown to play critical roles in development,
organogenesis, and the immune response. RA regulates expression of Alzheimer's disease …

Retinoic acid (RA) is known to cause the myeloid differentiation of HL-60 human
myeloblastic leukemia cells in a process requiring MEK-dependent ERK2 activation. This …

Klotho is an antiaging gene involved in the suppression of several age-related phenotypes,
but few studies have examined the mechanism underlying the regulation of human Klotho …

The network and balance of cytokines is of major importance in maintaining proper
homeostasis of hematopoiesis. Abnormalities in this network may result in a variety of blood …