Bmi-1, a polycomb gene family member, plays an important role in cell cycle regulation, cell
immortalization, and cell senescence. Recently, numerous studies have demonstrated that …

Cellular senescence is a major hurdle for primary cell-based tissue engineering and
regenerative medicine. Telomere erosion, oxidative stress, the expression of oncogenes …

Introduction Transplantation of genetically modified human bone marrow-derived
mesenchymal stem cells (hMSCs) with an accurate potential for chondrogenic differentiation …

Administration of mesenchymal stem cells (MSCs) that have a reliable potential for
chondrogenic differentiation is a promising approach currently employed to treat articular …

The infinite cell line is one of the most favored experimental tools and plays an irreplaceable
role in cell-based biological research. Primary cells from normal animal tissues undergo a …

Use of cells as therapeutic carriers has increased in the past few years and has developed
as a distinct concept and delivery method. Cell-based vehicles are particularly attractive for …

The hTERT-immortalization of human bone marrow-derived Mesenchymal Stromal Cells
(hMSCs) was proposed to address availability/standardization issues for experimental or …

Introduction The transplantation of genetically modified progenitor cells such as bone
marrow-derived mesenchymal stem cells (MSCs) is an attractive strategy to improve the …

In bone tissue reconstruction, the use of engineered constructs created by mesenchymal
stem cells (MSCs) that differentiate and proliferate into three-dimensional porous scaffolds is …

Multipotent mesenchymal stem cells (MSCs) are widely used as seed cells in studies of
tissue engineering and regenerative medicine; however, their clinical application is limited …