The ability of the body to maintain homeostasis requires constant communication between
the brain and peripheral tissues. Different organs produce signals, often in the form of …

Selenium (Se) is an essential trace element, which is inserted as selenocysteine (Sec) into
selenoproteins during biosynthesis, orchestrating their expression and activity. Se is …

Selenoprotein glutathione peroxidases (GPX), like ubiquitously expressed GPX1 and the
ferroptosis modulator GPX4, enact antioxidant activities by reducing hydroperoxides using …

The selenium element is essential to some life forms and its biological-chemistry function is
mainly performed by the selenol/selenolate moiety (–SeH/–Se–) in a few selenoproteins …

Introduction Antimicrobial resistance is a pressing global concern that has led to the search
for new antibacterial agents with novel targets or non-traditional approaches. Recently …

Abstract Thioredoxin reductase 1 (TrxR1) has emerged as a promising target for cancer
therapy. In our previous research, we discovered several new TrxR1 inhibitors and found …

Pulmonary fibrosis is highly lethal with limited treatments. Butaselen (BS) is an inhibitor of
thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor activity. However, its impact on …

Inhibiting thioredoxin reductase (TrxR) to disrupt the redox equilibrium and induce tumor cell
apoptosis is a significant tumor therapeutic strategy. Piperine, a natural product from black …

Overexpression of the selenoprotein thioredoxin reductase (TrxR) has been documented in
malignant tissues and is of pathological significance for many types of tumors. The antibiotic …

Selenium (Se) is a naturally occurring essential micronutrient that is required for human
health. Selenium supports cellular antioxidant defense and possesses bioeffects such as …