[HTML][HTML] Examining the biological mechanisms of human mental disorders resulting from gene-environment interdependence using novel functional genomic …

PP Silveira, MJ Meaney - Neurobiology of Disease, 2023 - Elsevier
We explore how functional genomics approaches that integrate datasets from human and
non-human model systems can improve our understanding of the effect of gene …

The schizophrenia syndrome, circa 2024: What we know and how that informs its nature

R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

[HTML][HTML] Time of exposure to social defeat stress during childhood and adolescence and redox dysregulation on long-lasting behavioral changes, a translational study

M Schnider, R Jenni, J Ramain, S Camporesi… - Translational …, 2022 - nature.com
Traumatic events during childhood/early adolescence can cause long-lasting physiological
and behavioral changes with increasing risk for psychiatric conditions including psychosis …

Changes in patterns of age-related network connectivity are associated with risk for schizophrenia

R Passiatore, LA Antonucci… - Proceedings of the …, 2023 - National Acad Sciences
Alterations in fMRI-based brain functional network connectivity (FNC) are associated with
schizophrenia (SCZ) and the genetic risk or subthreshold clinical symptoms preceding the …

[HTML][HTML] Schizophrenia: a narrative review of etiopathogenetic, diagnostic and treatment aspects

L Orsolini, S Pompili, U Volpe - Journal of Clinical Medicine, 2022 - mdpi.com
Although schizophrenia is currently conceptualized as being characterized as a syndrome
that includes a collection of signs and symptoms, there is strong evidence of heterogeneous …

[HTML][HTML] Considerations, caveats, and suggestions for the use of polygenic scores for social and behavioral traits

AL Non, JP Cerdeña - Behavior Genetics, 2024 - Springer
Polygenic scores (PGS) are increasingly being used for prediction of social and behavioral
traits, but suffer from many methodological, theoretical, and ethical concerns that profoundly …

Comparing pruning and thresholding with continuous shrinkage polygenic score methods in a large sample of ancestrally diverse adolescents from the ABCD study®

J Ahern, W Thompson, CC Fan, R Loughnan - Behavior genetics, 2023 - Springer
Using individuals' genetic data researchers can generate Polygenic Scores (PS) that are
able to predict risk for diseases, variability in different behaviors as well as anthropomorphic …

[HTML][HTML] Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review

LF Saccaro, A Aimo, G Panichella, O Sentissi - Frontiers in Psychiatry, 2024 - frontiersin.org
Introduction People with psychosis spectrum disorders (PSD) face an elevated risk of
metabolic syndrome (MetS), which may reduce their life expectancy by nearly 20 …

A Child–Parent Dyad Study on Adolescent Paranoia and the Influence of Adverse Life Events, Bullying, Parenting Stress, and Family Support

JL Kingston, L Ellett, EC Thompson… - Schizophrenia …, 2023 - academic.oup.com
Background Paranoid beliefs commonly occur in the general adolescent population.
Exposure to adverse life events (ALEs) and/or bullying are important environmental risk …

[HTML][HTML] Relationships between trauma types and psychotic symptoms: A network analysis of patients with psychotic disorders in a large, multi-country study in East …

A Stevenson, S Misra, E Girma, AM Isvoranu… - Comprehensive …, 2024 - Elsevier
Background The link between trauma exposure and psychotic disorders is well-established.
Further, specific types of trauma may be associated with specific psychotic symptoms …