Pathogenesis underlying neurological manifestations of long COVID syndrome and potential therapeutics

A Leng, M Shah, SA Ahmad, L Premraj, K Wildi… - Cells, 2023 - mdpi.com
The development of long-term symptoms of coronavirus disease 2019 (COVID-19) more
than four weeks after primary infection, termed “long COVID” or post-acute sequela of …

[HTML][HTML] Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions

AI Abulsoud, HM El-Husseiny, AA El-Husseiny… - Biomedicine & …, 2023 - Elsevier
COVID-19 is a worldwide pandemic caused by SARS-coronavirus-2 (SARS-CoV-2). Less
than a year after the emergence of the Covid-19 pandemic, many vaccines have arrived on …

Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID‐19 severity: A systematic review with meta‐analysis

W Saengsiwaritt, J Jittikoon… - Reviews in medical …, 2022 - Wiley Online Library
Abstract Novel coronavirus disease 2019 (COVID‐19) poses a global threat, due to its
fluctuating frequency and lethality. Published data revealed associations of COVID‐19 …

Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity

K Gupta, G Kaur, T Pathak, I Banerjee - Gene, 2022 - Elsevier
The COVID-19 pandemic has spawned global health crisis of unprecedented magnitude,
claiming millions of lives and pushing healthcare systems in many countries to the brink …

The impact of ACE2 polymorphisms on COVID-19 disease: susceptibility, severity, and therapy

F Chen, Y Zhang, X Li, W Li, X Liu… - Frontiers in Cellular and …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has currently spread worldwide, leading to high morbidity and …

Understanding the pharmacology of COVID-19 mRNA vaccines: playing dice with the spike?

M Cosentino, F Marino - International journal of molecular sciences, 2022 - mdpi.com
Coronavirus disease-19 (COVID-19) mRNA vaccines are the mainstays of mass vaccination
campaigns in most Western countries. However, the emergency conditions in which their …

SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease

N Alimoradi, M Sharqi, D Firouzabadi, MM Sadeghi… - Virology Journal, 2022 - Springer
COVID-19 and the renin-angiotensin system (RAS) are linked by angiotensin-converting
enzyme 2 (ACE2), a key enzyme in RAS that has been validated as a SARS-CoV-2 receptor …

COVID-19–associated lung microvascular endotheliopathy: a “from the bench” perspective

J Joffre, L Rodriguez, ZA Matthay, E Lloyd… - American Journal of …, 2022 - atsjournals.org
Rationale: Autopsy and biomarker studies suggest that endotheliopathy contributes to
coronavirus disease (COVID-19)-associated acute respiratory distress syndrome. However …

Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis

C Dieter, LA Brondani, CB Leitão, F Gerchman… - PLoS …, 2022 - journals.plos.org
Although advanced age and presence of comorbidities significantly impact the variation
observed in the clinical symptoms of COVID-19, it has been suggested that genetic variants …

Host genetic polymorphisms involved in long-term symptoms of COVID-19

W Udomsinprasert, N Nontawong… - Emerging Microbes & …, 2023 - Taylor & Francis
Host genetic polymorphisms are recognized as a critical determinant of diversity in clinical
symptoms of Coronavirus disease 2019 (COVID-19). Accordingly, this study aimed to …